THE CLINICAL-SIGNIFICANCE OF CALCULATED VERSUS MEASURED CREATININE CLEARANCE IN PATIENTS WITH GYNECOLOGIC MALIGNANCY

Measurement of creatinine clearance remains inconvenient because of th e need for 24-hour urine collection, Our study compared creatinine cle arance calculated from serum creatinine (CCalpha) to measured creatini ne clearance (MC(alpha)) using an unsupervised 8-hour urine collection at home, Forty-two women admitted to our gynecologic oncology service participated in this study, Twenty-six of these patients had cancer o riginating from the ovaries, 8 from the uterus, 7 from the cervix, and 1 from the fallopian tube, There were adequate data for 61 collection s, MC(alpha) using unsupervised 8-hour urine collection at home correl ated well with CCalpha. This calculated value may be sufficient to be used as a guide in evaluating renal function in patients with gynecolo gic malignancy, However, if it becomes necessary to measure creatinine clearance, our data suggest that an 8-hour collection may be used.