MIGRAINOUS DISORDER AND ITS RELATION TO MIGRAINE WITHOUT AURA AND MIGRAINE WITH AURA - A GENETIC EPIDEMIOLOGIC-STUDY

Migrainous disorder was analysed in a large population-based study of 4000 forty-year-old males and females. All interviews were conducted b y one physician and the diagnostic criteria of the International Heada che Society were used. Of the 48 people with migrainous disorder, 40 h ad migrainous disorder without aura and 9 had migrainous disorder with aura. One person had co-occurrence of migrainous disorder with and wi thout aura. The lifetime prevalence of migrainous disorder was 2.5% wi th a male:female ratio of 1 : 1.2. The first-degree relatives of proba nds with migrainous disorder were blindly interviewed. Compared with t he general population, first-degree relatives of probands with migrain ous disorder without aura had a slightly but less increased risk of mi graine without aura than first-degree relatives of probands with migra ine without aura. First-degree relatives of probands with migrainous d isorder with aura had no increased risk of migraine with aura. We conc lude that migrainous disorder without aura in some people is a type of migraine without aura and in other people not. Migrainous disorder wi th aura may be unrelated to migraine with aura.