Endoscopic sinus surgery (ESS) is one of the most commonly performed p
rocedures in otorhinolaryngology and is associated with a definite ris
k for both intraoperative and postoperative complications. Intraoperat
ive image guidance is expected to have a major effect on procedures su
ch as ESS by allowing the clinician to more efficiently remove patholo
gy and by improving surgeon confidence and knowledge of anatomy, parti
cularly in revision procedures or in patients with altered anatomy. As
a consequence, complications during these procedures will decrease an
d patient safety well increase. Several guidance modalities are availa
ble including computed tomography (CT), magnetic resonance imaging (MR
I), and fluoroscopy. This article will describe current applications o
f each of these three techniques with respect to ESS while focusing on
innovative techniques that use MRI and CT to provide intraoperative g
uidance with unmatched convenience, reliability, and utility.