LORACARBEF - SINUS TISSUE PENETRATION AFTER SINGLE-DOSE ADMINISTRATION

The underlying basis of the antibiotic treatment of sinusitis is still unclear. Critical to the use of antibiotics in patients with sinusiti s is the tissue penetration of the curative agent. However, there is s cant information available regarding maxillary mucosal tissue levels i n patients with this disease. We present the results of plasma and sin us tissue concentrations of loracarbef in six patients and one control . Levels were taken at 2 and 3 hours after the oral administration of the medication. The mean sinus tissue level was 2.5 mcg/gm and 2.7 mcg /gm at 2 and 3 hours after administration respectively. Although thera peutic efficacy cannot be predicted by the concentrations attained in a specific body fluid or tissue, we believe that these levels are exce llent based on mean inhibitory concentrations. Additional studies are underway to document the penetration of this and comparable other drug s in multiple sinuses.