A CASE OF LEUKOCYTE ADHESION DEFICIENCY (LAD) PRESENTING WITH NASAL-SEPTUM PERFORATION AND NECROTIZING ULCER ON ALA NASI

We report on a 3 month-old female patient having leukocyte adhesion de ficiency (LAD) of severe phenotype presenting with perforation of the nasal septum and ulceration on the right ala nasi. Laboratory investig ations revealed marked leukocytosis, defective nentrophil adherence to glass beads and chemotaxis, decreased NK cell cytotoxicity, and undet ectable expression of CD18 on lymphocytes. We conclude that the possib ility of this entity should be kept in mind in the presence of such a necrotic lesion in early childhood.