SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA) .1. 6-METHYL DERIVATIVES

Authors
AITKEN RA BIBBY MC DOUBLE JA PHILLIPS RM SHARMA SK
Citation
Ra. Aitken et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA) .1. 6-METHYL DERIVATIVES, Archiv der pharmazie, 329(11), 1996, pp. 489-497
Citations number
37
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
329
Issue
11
Year of publication
1996
Pages
489 - 497
Database
ISI
SICI code
0365-6233(1996)329:11<489:SAAOND>2.0.ZU;2-Z
Abstract
A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-meth yl substituent have been prepared and their anti-tumour activity evalu ated in vitro against a panel of human and murine tumour cell lines an d in vivo against MAC 15A. While many of the compounds show activity c omparable to FAA in vitro, this essentially disappears in vivo, possib ly due to degradation before the compounds can reach the tumour site.