LESER-TRELAT SIGN WITH ANAPLASTIC EPENDYMOMA - AN AUTOPSY CASE

A 36-year-old Japanese male, who 7 years previously had been diagnosed as having an ependymoma in the left parietal region, had received sur gery, chemotherapy and radiotherapy. He later developed a rapid growth of multiple skin lesions on his back and extremities, which coincided with a regrowth of the tumor. Post-mortem examination revealed that t he ependymoma showed anaplastic transformation and necrosis; however, no malignancy was observed in the extracranial organs. The skin lesion s were histologically diagnosed as seborrheic keratoses. We have, ther efore, diagnosed the patient as having Leser-Trelat sign associated wi th anaplastic ependymoma.