As consumption of dietary fructose and sorbitol increases, the associa
tion between consumption of these sugars and gastrointestinal symptoms
has been recognized. As a result, studies of fructose and sorbitol ab
sorption and malabsorption have emerged with investigations relying la
rgely on the use of breath hydrogen (H-2) measurements. Since these su
gars are prevalent in fruit juices, a major dietary staple in the firs
t 5 years of life, an understanding of fructose and sorbitol absorptio
n is particularly important to pediatric health care providers. This r
eview examines fructose and sorbitol absorption in humans, reviewing a
s well the breath H, method upon which studies of fructose and sorbito
l absorption largely depend.