ANTIOXIDANT ACTIVITY OF A DIHYDROQUERCETIN ISOLATED FROM LARIX GMELINII (RUPR) RUPR WOOD

Citation
Vk. Kolhir et al., ANTIOXIDANT ACTIVITY OF A DIHYDROQUERCETIN ISOLATED FROM LARIX GMELINII (RUPR) RUPR WOOD, PTR. Phytotherapy research, 10(6), 1996, pp. 478-482
Citations number
21
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
ISSN journal
0951418X
Volume
10
Issue
6
Year of publication
1996
Pages
478 - 482
Database
ISI
SICI code
0951-418X(1996)10:6<478:AAOADI>2.0.ZU;2-Z
Abstract
We have demonstrated that dihydroquercetin is an antioxidant and posse sses the properties of protecting capillaries, which is consistent wit h its action as an antiinflammatory agent, gastro- and hepatoprotectin g agent, and its diuretic and hypolipidaemic activity, As a capillary protector, dihydroquercetin is 3.4 times more effective at a dose of 1 00 mg/kg and 4.9 times at a dose of 300 mg/kg than the well known biof lavonoid, quercetin. Dihydroquercetin shows a dose dependent suppressi on of lipid peroxidation in the rat liver, The hypolipidaemic activity of dihydroquercetin at 250 mg/kg is comparable to that of polysponin.