SUPPRESSION OF HEPATITIS-B VIRUS SURFACE-ANTIGEN SECRETION BY TRADITIONAL PLANT MEDICINES

Authors
GOTO W KUSUMOTO IT KADOTA S NAMBA T KUROKAWA M SHIRAKI K
Citation
W. Goto et al., SUPPRESSION OF HEPATITIS-B VIRUS SURFACE-ANTIGEN SECRETION BY TRADITIONAL PLANT MEDICINES, PTR. Phytotherapy research, 10(6), 1996, pp. 504-507
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
10
Issue
6
Year of publication
1996
Pages
504 - 507
Database
ISI
SICI code
0951-418X(1996)10:6<504:SOHVSS>2.0.ZU;2-9
Abstract
Forty-three extracts of herbal medicines were tested for suppressing t he secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in vit ro, Fourteen extracts were found to have appreciable effects in the ex perimental system using the PLC/PRF/5 cell line, Of them, the extracts of Rheum palmatum (rhizome), Poligonum cuspidatum (root), Panax japon icum (root) and Terminalia arjuna (bark) strongly suppressed the secre tion of HBsAg, The active constituents of these extracts absorbed thro ugh the gastrointestinal tract of guinea-pigs suppressed the secretion of HBsAg in the PLC/PRF/5 cell culture.