ANALYSIS OF EFFECT OF 2 CONCURRENT ISCHEMIC ZONES ON LEFT-VENTRICULARFUNCTION

Left ventricular (LV) function due to two concurrent ischaemic zones ( IZs) is investigated using a cardiovascular system model. The model co mprises a three-compartment LV, the venous return and the arterial sys tem. Haemodynamic responses of the LV to changes in the IZ size and my ocardial contraction timings are explored. Results show that the great er the degree of asynschonisation is between the normal zone and the I Z, and the larger the ischaemic size, the more severe the LV dysfuncti on. Pre-load augmentation improves LV function. Model-predicted featur es are consistent with reported observations associated with myocardia l ischaemia. The extent of the usefulness and limitations of this mode l is also discussed.