This exposure study addresses the validity of the exposure assessment
method of an epidemiological study of traffic-related air pollution an
d childhood cancer. In particular, this paper concerns the question of
whether the concentration of nitrogen dioxide (NO2) outside the front
door is a valid marker of the exposure of the child living at the add
ress. The study includes 100 children living on streets with dense tra
ffic in central parts of Copenhagen and 100 children living in rural a
reas. Preliminary results, based on 25% of the study subjects, suggest
that both the outdoor NO2-concentration and the exposure of the child
ren are two to three times higher in Copenhagen than in the rural dist
ricts. Moreover, the results suggest that the NO2-concentration outsid
e the front door is a poor marker of the exposure of the children in C
openhagen, but a marker of some relevance for the exposure of the chil
dren in rural districts. The preliminary results must be treated with
caution, as among other things, the analysis did not consider seasonal
changes and indoor NO2-sources such as passive smoking, candles, and
gas appliances.