The holmium:YAG (Ho:YAG) laser wavelength's ability to vaporize and in
cise soft tissue offers potential advantages for prostatectomy compare
d with the Nd:YAG laser, which primarily produces tissue coagulation,
In this initial U.S. trial, Ho:YAG laser prostatectomy was performed i
n 20 men, including 2 men treated immediately prior to radical prostat
ectomy to assess Ho:YAG laser tissue effects in the prostate, A total
of 18 men were treated for clinically symptomatic bladder outlet obstr
uction secondary to benign prostatic hyperplasia (BPH), Estimated exce
ss BPH tissue averaged 24 g (range 5-50 g), A mean of 129 kJ of Ho:YAG
laser energy was delivered, combined with a mean of 11 kJ of Nd:YAG e
nergy to provide supplemental coagulation for hemostasis, The mean ope
rative time was 1 hour 34 minutes, No significant intraoperative chang
es in hematocrit or serum electrolytes were documented, No perioperati
ve or late complications occurred, The mean postoperative catheterizat
ion time was 1.4 days, Of the 18 patients, 16 (90%) underwent a succes
sful voiding trial on the first postoperative morning, Immediate impro
vement in voiding, comparable to that seen after transurethral electro
cautery resection of the prostate (TURF), was reported by all patients
, Ho:YAG laser resection of the prostate appears to be a useful surgic
al technique associated with minimal morbidity and immediate improveme
nt in voiding.