PLATELET-ACTIVATING-FACTOR AND SOMATOSTATIN ACTIVATE MITOGEN-ACTIVATED PROTEIN-KINASE (MAP KINASE) AND ARACHIDONATE RELEASE

Authors
SHIMIZU T MORI M BITO H SAKANAKA C TABUCHI S AIHARA M KUME K
Citation
T. Shimizu et al., PLATELET-ACTIVATING-FACTOR AND SOMATOSTATIN ACTIVATE MITOGEN-ACTIVATED PROTEIN-KINASE (MAP KINASE) AND ARACHIDONATE RELEASE, Journal of lipid mediators and cell signalling, 14(1-3), 1996, pp. 103-108
Citations number
22
Categorie Soggetti
Biology,"Cell Biology
Journal title
Journal of lipid mediators and cell signalling → ACNP
ISSN journal
09297855
Volume
14
Issue
1-3
Year of publication
1996
Pages
103 - 108
Database
ISI
SICI code
0929-7855(1996)14:1-3<103:PASAM>2.0.ZU;2-U
Abstract
Platelet-activating factor (PAF) receptor and somatostatin receptor (S STR4) were cloned, and their primary structures were identified. They are both highly expressed in the rat hippocampus. When expressed in Ch inese hamster ovary cells, these receptors activated mitogen-activated protein (MAP) kinase cascade and phospholipase A(2). Arachidonic acid or its derivatives, thus produced by the activation of these receptor s may play some roles in synaptic transmission and synaptic plasticity .