EXPEDIENT ENANTIOSPECIFIC SYNTHESIS OF RP-73613 - A NEW SELECTIVE NONPEPTIDE NK1 ANTAGONIST

Authors
DAUBIE C MUTTI S
Citation
C. Daubie et S. Mutti, EXPEDIENT ENANTIOSPECIFIC SYNTHESIS OF RP-73613 - A NEW SELECTIVE NONPEPTIDE NK1 ANTAGONIST, Tetrahedron letters, 37(43), 1996, pp. 7743-7744
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
43
Year of publication
1996
Pages
7743 - 7744
Database
ISI
SICI code
0040-4039(1996)37:43<7743:EESOR->2.0.ZU;2-I
Abstract
The synthesis of RP 73613 was achieved in 13 steps with an overall yie ld of 12%. The strategy was based on a [3 + 2] azomethine ylid dipolar cycloaddition to generate the bicyclic framework and the asymmetry wa s introduced by resolution. Copyright (C) 1996 Elsevier Science Ltd