T-BUTYLDIMETHYLSILYLOXYMETHYL GROUP, A VERSATILE PROTECTING GROUP OF ADENINE

Authors
MAGNIN GC DAUVERGNE J BURGER A BIELLMANN JF
Citation
Gc. Magnin et al., T-BUTYLDIMETHYLSILYLOXYMETHYL GROUP, A VERSATILE PROTECTING GROUP OF ADENINE, Tetrahedron letters, 37(43), 1996, pp. 7833-7836
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
43
Year of publication
1996
Pages
7833 - 7836
Database
ISI
SICI code
0040-4039(1996)37:43<7833:TGAVPG>2.0.ZU;2-L
Abstract
The successive treatment of adenine with formaldehyde in basic conditi ons and with t-butyldimethylsilyl trifluoromcthanesulfonate gave regio selectively 9-t-butyl-dimethylsilyloxymethyl-adenine 2 in a yield of 6 5%. This derivative 2 was soluble in most organic solvents. The silyl group was removed under acidic conditions. Copyright (C) 1996 Elsevier Science Ltd