Va. Soloshonok et al., TRANSITION-METAL-CATALYZED DIASTEREOSELECTIVE ALDOL REACTIONS OF PROCHIRAL KETONES WITH METHYL ISOCYANOACETATE, Tetrahedron letters, 37(43), 1996, pp. 7845-7848
Systematic study of the transition metal-catalyzed aldol reactions of
certain prochiral ketones with methyl isocyanoacetate has been made. H
igh diastereoselectivity (80-98% de) of these condensations, leading t
o methyl -dihydro-5,5-(disubstituted)-4-oxazolecarboxylates was shown
to be controlled by the nature of both catalyst and substituents on th
e starting ketone. Copyright (C) 1996 Elsevier Science Ltd