SYNTHESIS OF TUMOR-ASSOCIATED SACCHARIDES VIA O-GLYCOSYL TRICHLOROACETIC

Authors
ZHU XX DING PY CAI MS
Citation
Xx. Zhu et al., SYNTHESIS OF TUMOR-ASSOCIATED SACCHARIDES VIA O-GLYCOSYL TRICHLOROACETIC, Tetrahedron : asymmetry, 7(10), 1996, pp. 2833-2838
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
10
Year of publication
1996
Pages
2833 - 2838
Database
ISI
SICI code
0957-4166(1996)7:10<2833:SOTSVO>2.0.ZU;2-F
Abstract
The trichloroacetic method was employed to synthesize di- and hexa-sac charides. O-glycosyl trichloroacetic, a stable and readily obtained in termediate, was activated to give a highly reactive glycosyl donor upo n treatment with acid and coupled with the acceptor to afford complex glycosides with high stereoselectivity and in good yield. Two free hex asaccharides will be used to explore the possible prevention of metast atic spread. Copyright (C) 1996 Published by Elsevier Science Ltd