Last week, A. Sen found an explicit type I string compactification dua
l to the eight-dimensional F-theory construction with SO(8)(4) nonabel
ian gauge symmetry. He found that the perturbations around the enhance
d symmetry point were described by the mathematics of the solution of
N = 2, d = Lf SU(2) gauge theory with four flavors, and argued more ge
nerally that global symmetry enhancement in N = 2, d = 4 gauge theorie
s corresponded to gauge symmetry enhancement in F-theory. We show that
these N = 2, d = 4 gauge theories have a physical interpretation in t
he theory. They are the world-volume theories of 3-branes parallel to
the 7-branes. They can be used to probe the structure of the exact qua
ntum F-theory solutions. On the Higgs branch of the moduli space, the
objects are equivalent to finite size instantons in the 7-brane gauge
theory.