Sm. Sastry et al., COMBINED GANCICLOVIR AND FOSCARNET IN PEDIATRIC CYTOMEGALOVIRUS RETINITIS, Journal of the National Medical Association, 88(10), 1996, pp. 661-662
Cytomegalovirus retinitis is the leading cause of blindness in adults
and children with acquired immunodeficiency syndrome (AIDS), Although
clinical trials on therapy exist for adults, management of cytomegalov
irus retinitis in children is not as well-documented. This report desc
ribes the clinical course of a 3-year-old child with cytomegalovirus r
etinitis, After initial failure with single-agent ganciclovir intraven
ous treatment, early institution of combined treatment with foscarnet
and ganciclovir halted progression of the retinitis, This case report
highlights the aggressive nature of cytomegalovirus retinitis in child
ren and the consideration of early combined therapy compared to adult
patients.