HEMOSTASIS PARAMETERS DURING OVARIAN STIMULATION FOR IN-VITRO FERTILIZATION - RESULTS OF A PROSPECTIVE-STUDY

Objective: To evaluate the effect of IVF-ET on the hemostatic system. Design: Prospective clinical study. Setting: Apparently healthy age-ma tched women of the hospital staff at various stage of the menstrual cy cle. Patient(s): Twenty-five women involved in a IVF-ET program at the Department of Obstetrics and Gynecology, Montpellier University Hospi tal. Intervention(s): Twenty-six hemostasis parameters evaluated repea tedly in patients undergoing IVF-ET. Main Outcome Measure(s): Blood ce ll-dependent hemostasis parameters and plasmatic coagulation factors, determined at pituitary desensitization, maximal E(2) level, and P pla teau. Result(s): Activation of the hemostatic system is evidenced at t he P plateau, when D-dimers and fragments 1 + 2 of the prothrombin lev els rose dramatically. At E(2) peak, no significant modification of he mostasis markers was noted. Conclusion(s): The present results indicat e that ovarian hyperstimulation may induce hemostasis activation at th e P plateau. The role of supraphysiologic sea hormone levels on the he mostatic system requires further investigation.