BMS-187257, A POTENT, SELECTIVE, AND NOVEL HETEROCYCLIC BETA(3) ADRENERGIC-RECEPTOR AGONIST

Authors
FISHER LG SHER PM SKWISH S MICHEL IM SEILER SM DICKINSON KEJ
Citation
Lg. Fisher et al., BMS-187257, A POTENT, SELECTIVE, AND NOVEL HETEROCYCLIC BETA(3) ADRENERGIC-RECEPTOR AGONIST, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2253-2258
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2253 - 2258
Database
ISI
SICI code
0960-894X(1996)6:19<2253:BAPSAN>2.0.ZU;2-A
Abstract
Novel heterocyclic beta(3) adrenergic receptor agonists(2) were prepar ed and evaluated for their ability to bind to human beta(1), beta(2), and beta(3) adrenergic receptors. Stimulatory effects on the beta(3) a drenergic receptor were also measured. BMS-187257 (4b) was found to be a potent and selective beta(3) agonist. Copyright (C) 1996 Elsevier S cience Ltd