NEW CLASS OF POTENT LIGANDS FOR THE HUMAN PERIPHERAL CANNABINOID RECEPTOR

Authors
GALLANT M DUFRESNE C GAREAU Y GUAY D LEBLANC Y PRASIT P ROCHETTE C SAWYER N SLIPETZ DM TREMBLAY N METTERS KM LABELLE M
Citation
M. Gallant et al., NEW CLASS OF POTENT LIGANDS FOR THE HUMAN PERIPHERAL CANNABINOID RECEPTOR, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2263-2268
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2263 - 2268
Database
ISI
SICI code
0960-894X(1996)6:19<2263:NCOPLF>2.0.ZU;2-C
Abstract
A new class of potent ligand for the human peripheral cannabinoid (hCB (2)) receptor is described. Two indole analogs 13 and 17 exhibited nan omolar potencies (K-i) with good selectivity for the hCB(2) receptor o ver the human central cannabinoid (hCB(1)) receptor. Copyright (C) 199 6 Elsevier Science Ltd