ATTACHMENT OF A STYRYL GROUP TO THE 6-POSITION OF A PROTECTED PENICILLANIC ACID VIA COBALOXIME-MEDIATED RADICAL ALKYL-ALKENYL CROSS-COUPLING

Authors
DETLEFSEN WD BRANCHAUD BP
Citation
Wd. Detlefsen et Bp. Branchaud, ATTACHMENT OF A STYRYL GROUP TO THE 6-POSITION OF A PROTECTED PENICILLANIC ACID VIA COBALOXIME-MEDIATED RADICAL ALKYL-ALKENYL CROSS-COUPLING, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2289-2292
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2289 - 2292
Database
ISI
SICI code
0960-894X(1996)6:19<2289:AOASGT>2.0.ZU;2-J
Abstract
Cobaloxime-catalyzed cross coupling of styrene with 6 alpha-bromopenic illanic acid pivalolyloxymethyl ester (4) introduces a styryl group in to the 6 position of the penicillanic acid nucleus. The method should be capable of introducing a variety of aryl-substituted alkenes into t he 6 position. Such compounds may be useful as novel beta-lactam antib iotics/beta-lactamase inhibitors. Copyright (C) 1996 Elsevier Science Ltd