NOVEL ANALOGS OF CYCLIC-ADP-RIBOSE - 9-CYCLIC ETHENO-ADP-RIBOSE AND CYCLIC ETHENO-CDP-RIBOSE

Authors
ZHANG FJ SIH CJ
Citation
Fj. Zhang et Cj. Sih, NOVEL ANALOGS OF CYCLIC-ADP-RIBOSE - 9-CYCLIC ETHENO-ADP-RIBOSE AND CYCLIC ETHENO-CDP-RIBOSE, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2311-2316
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2311 - 2316
Database
ISI
SICI code
0960-894X(1996)6:19<2311:NAOC-9>2.0.ZU;2-2
Abstract
Two novel analogs of cyclic ADP-ribose (cADPR), 9-cyclic etheno-ADP-ri bose (1) and cyclic etheno-CDP-ribose (2) were synthesized. We have sh own for the first time that enzymatic and biomimetic methods may proce ed by different reaction pathways. 1,N-6-Etheno-nicotinamide-adenine d inucleotide (3) was converted into 1 using the biomimetic procedure, w hereas ADP-ribosyl cyclase transformed 3 into 4. The unique fluorescen ce property and the strong Ca2+ mobilizing activity of 1 provide inves tigators with a useful probe for the study of cADPR-binding proteins. Copyright (C) 1996 Elsevier Science Ltd