THIOL INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME

Authors
DEPREZ P GUILLAUME J DUMAS J VEVERT JP
Citation
P. Deprez et al., THIOL INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2317-2322
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2317 - 2322
Database
ISI
SICI code
0960-894X(1996)6:19<2317:TIOEE>2.0.ZU;2-6
Abstract
Synthesis and structure activity relationships of a series of thiol in hibitors of the endothelin-converting enzyme (ECE) are presented. Opti misation of the stereochemistry as well as of the P'(1) and P'(2) resi dues led to inhibitors with similar potency to that of phosphoramidon. Copyright (C) 1996 Elsevier Science Ltd