IRL-2500 - A POTENT ET(B) SELECTIVE ENDOTHELIN ANTAGONIST

Authors
FRUH T SAIKA H SVENSSON L PITTERNA T SAKAKI J OKADA T URADE Y ODA K FUJITANI Y TAKIMOTO M YAMAMURA T INUI T MAKATANI M TAKAI M UMEMURA I TENO N TOH H HAYAKAWA K MURATA T
Citation
T. Fruh et al., IRL-2500 - A POTENT ET(B) SELECTIVE ENDOTHELIN ANTAGONIST, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2323-2328
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2323 - 2328
Database
ISI
SICI code
0960-894X(1996)6:19<2323:I-APES>2.0.ZU;2-C
Abstract
Combination of a glycine substitution scan on the C-terminal dodecapep tide analog of ET-1 and a substance P antagonist screen on the basis o f a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) sele ctive endothelin antagonist. Copyright (C) 1996 Published by Elsevier Science Ltd