OXIDATION OF RETINYL ACETATE AND ANALOGS BY NITRIC-OXIDE AND NITROGEN-DIOXIDE

Authors
AFZAL M WALTON JC
Citation
M. Afzal et Jc. Walton, OXIDATION OF RETINYL ACETATE AND ANALOGS BY NITRIC-OXIDE AND NITROGEN-DIOXIDE, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2329-2332
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2329 - 2332
Database
ISI
SICI code
0960-894X(1996)6:19<2329:OORAAA>2.0.ZU;2-B
Abstract
Nitric oxide did not react directly with retinyl acetate but, in the p resence of an initiator, a series of nitroxide radicals was produced a nd observed by EPR spectroscopy. Product analyses showed that rapid ox idative degradation of retinyl acetate gave a series of carbonyl compo unds. NO operating in concert with a self-derived initiator such as NO 2 on unsaturated lipids could account for the cytotoxicity of this mol ecule. Copyright (C) 1996 Elsevier Science Ltd