Se. Osborne et Ad. Ellington, INCORPORATING DISULFIDE CROSS-LINKS AT THE TERMINUS OF OLIGONUCLEOTIDES VIA SOLID-PHASE NUCLEIC-ACID SYNTHESIS, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2339-2342
A new reagent has been prepared that allows disulfide cross-links to b
e introduced into nucleic acids during solid-phase synthesis. The disu
lfide is formed between thioalkyl tethers at the N-3-position of thymi
dines and stabilizes the termini of nucleic acid helices. This reagent
should be especially useful for synthesizing small but stable nucleic
acid structures. Copyright (C) 1996 Elsevier Science Ltd