INCORPORATING DISULFIDE CROSS-LINKS AT THE TERMINUS OF OLIGONUCLEOTIDES VIA SOLID-PHASE NUCLEIC-ACID SYNTHESIS

Authors
OSBORNE SE ELLINGTON AD
Citation
Se. Osborne et Ad. Ellington, INCORPORATING DISULFIDE CROSS-LINKS AT THE TERMINUS OF OLIGONUCLEOTIDES VIA SOLID-PHASE NUCLEIC-ACID SYNTHESIS, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2339-2342
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2339 - 2342
Database
ISI
SICI code
0960-894X(1996)6:19<2339:IDCATT>2.0.ZU;2-N
Abstract
A new reagent has been prepared that allows disulfide cross-links to b e introduced into nucleic acids during solid-phase synthesis. The disu lfide is formed between thioalkyl tethers at the N-3-position of thymi dines and stabilizes the termini of nucleic acid helices. This reagent should be especially useful for synthesizing small but stable nucleic acid structures. Copyright (C) 1996 Elsevier Science Ltd