HYDROPHOBIC EFFECTS IN DUPLEXES WITH MODIFIED OLIGONUCLEOTIDE BACKBONES AND RNA

Authors
WALDNER A DEMESMAEKER A WENDEBORN S
Citation
A. Waldner et al., HYDROPHOBIC EFFECTS IN DUPLEXES WITH MODIFIED OLIGONUCLEOTIDE BACKBONES AND RNA, Bioorganic & medicinal chemistry letters, 6(19), 1996, pp. 2363-2366
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
19
Year of publication
1996
Pages
2363 - 2366
Database
ISI
SICI code
0960-894X(1996)6:19<2363:HEIDWM>2.0.ZU;2-L
Abstract
The incorporation of hydrophobic substituents on the amide functionali ty of modified oligonucleotides drastically influences the thermal sta bility of the corresponding duplexes with the RNA complement. Copyrigh t (C) 1996 Elsevier Science Ltd