GELATIN-ACACIA COMPLEX COACERVATION AS A METHOD FOR KETOPROFEN MICROENCAPSULATION

Ketoprofen microcapsules were prepared by complex coacervation between gelatin and acacia, and dried with different methods: isopropanol add ition, spray-drying, and freeze-drying, Successively, microparticles w ere analyzed by infrared thermobalance, ultraviolet spectroscopy, opti cal and scanning electron microscopy, and sieves; and subjected to dis solution studies in order to examine parameters such as yield, moistur e content, encapsulation percentage, morphology of solid particles, pa rticle size, and dissolution behavior. Provided that encapsulation and drying methods did not affect ketoprofen dissolution profiles, the mo st appropriate drying method for industrial purposes was spray-drying.