FORMULATION STUDIES OF FUROSEMIDE-AMILORIDE HCL COMBINATION TABLETS

During the formulation studies of a furosemide-amiloride HCl combinati on tablet, an unexpected interaction between the two drugs was encount ered. The drugs tended to form aggregates when in contact with the dis solution medium during dissolution testing. This phenomenon decreased the dissolution of both actives significantly. Various formulas were t ried to eliminate this problem. Granulation of the formulation with po vidone produced a tablet with good dissolution properties. A possible mechanism for preventing the formation of furosemide-amiloride HCl agg regates in the presence of povidone is described.