PREPARATION AND CHARACTERIZATION BY ELECTROSPRAY MASS-SPECTROMETRY OFCATIONIC METALLOPORPHYRIN DNA CLEAVERS

Authors
BIGEY P FRAU S LOUP C CLAPAROLS C BERNADOU J MEUNIER B
Citation
P. Bigey et al., PREPARATION AND CHARACTERIZATION BY ELECTROSPRAY MASS-SPECTROMETRY OFCATIONIC METALLOPORPHYRIN DNA CLEAVERS, Bulletin de la Societe chimique de France, 133(7-8), 1996, pp. 679-689
Citations number
53
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
133
Issue
7-8
Year of publication
1996
Pages
679 - 689
Database
ISI
SICI code
0037-8968(1996)133:7-8<679:PACBEM>2.0.ZU;2-X
Abstract
Cationic metalloporphyrin derivatives endowed with nuclease activity h ave been prepared and characterized by electrospray mass spectrometry. These metalloporphyrin precursors have various functionalized tethers and are excellent DNA cleavers to be linked to an oligonucleotide or a minor groove binder like Hoechst 33258, a bis-benzimidazole DNA dye.