EFFECT OF ANTIHYPERTENSIVE TREATMENT ON LIPIDS AND FIBRINOGEN - GREEKMULTICENTER STUDY OF CILAZAPRIL

The effect of cilazapril (CLZ) treatment on serum lipids and fibrinoge n was studied in 114 hypertensive patients for 18 weeks. Blood pressur e, heart rate, lipid profile and fibrinogen were measured before and a t the end of the study in all patients, Satisfactory blood pressure co ntrol was seen in 68% of the patients (group A) after 4 weeks of treat ment with 5 mg CLZ monotherapy, while a single dose of chlorthalidone, 25 mg daily, was added to the therapeutic regimen of the remaining 32 % of patients (group B) to achieve blood pressure control, We conclude that CLZ has a slight beneficial effect on the lipid profile and a si gnificantly beneficial effect on fibrinogen, but its combination with a diuretic reverses this beneficial effect.