POLAROGRAPHIC-BEHAVIOR OF 5-PHENYLAZOPYRIMIDINETRIONE AND ITS SUBSTITUTED DERIVATIVES

Authors
HELMY AMA KHALIL RM MORSI MA
Citation
Ama. Helmy et al., POLAROGRAPHIC-BEHAVIOR OF 5-PHENYLAZOPYRIMIDINETRIONE AND ITS SUBSTITUTED DERIVATIVES, Chemical and Pharmaceutical Bulletin, 44(10), 1996, pp. 1779-1784
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
10
Year of publication
1996
Pages
1779 - 1784
Database
ISI
SICI code
0009-2363(1996)44:10<1779:PO5AIS>2.0.ZU;2-U
Abstract
The polarographic behavior of 5-phenylazo-2-thiobarbituric acid and 5 of its substituted derivatives was investigated in a buffer solution o f pH (2-12). A mechanism for the reduction pathway is suggested. Based on the results of the nitro derivative, the coupling product of 2-thi obarbituric acid with diazonium salt is most probably in the azo and n ot the hydrazone form. The most reliable E(1/2) values at different pH 's were correlated to Hammett's sigma constant which reflected a fair correlation.