ABSOLUTE STEREOCHEMISTRY OF (-)-PREORIXINE AND RELATED-COMPOUNDS

Authors
FUNAYAMA S MURATA K NOZOE S
Citation
S. Funayama et al., ABSOLUTE STEREOCHEMISTRY OF (-)-PREORIXINE AND RELATED-COMPOUNDS, Chemical and Pharmaceutical Bulletin, 44(10), 1996, pp. 1885-1889
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
10
Year of publication
1996
Pages
1885 - 1889
Database
ISI
SICI code
0009-2363(1996)44:10<1885:ASO(AR>2.0.ZU;2-L
Abstract
The absolute stereochemistry of the C-2' position of(-)-preorixine, po stulated to be an important biosynthetic precursor of various quinolin e alkaloids, was assigned as R by the combination of its chemical tran sformation and the extended Mosher method. The stereochemistry of the C-2' position of (+)-orixine was also concluded to be R, establishing that no inversion occurred when(-)-preorixine was transformed into (+) -orixine.