NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY

Authors
FUKUTOMI R KAGECHIKA H HASHIMOTO Y SHUDO K
Citation
R. Fukutomi et al., NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY, Chemical and Pharmaceutical Bulletin, 44(10), 1996, pp. 1983-1985
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
10
Year of publication
1996
Pages
1983 - 1985
Database
ISI
SICI code
0009-2363(1996)44:10<1983:NAUDWD>2.0.ZU;2-Z
Abstract
Several aromatic urea derivatives were designed and synthesized as DNA -targeting agents, 4-amidylphenyl)amino-carbonyl]-2,6-diaminopyridine (1) and 1,3-bis[5-(glycylamino)pyrid-2-yl]urea (3) showed remarkable D NA-binding abilities as determined by ultrafiltration assay using calf thymus DNA, their potencies being equal to and half that of netropsin , respectively. Compound 1 inhibited the proliferation of both L1210 c ells and KB cells with similar IC50 values to netropsin.