CONVENIENT ACCESS TO 3,4,5-TRISUBSTITUTED PYRIDINES

The reaction of 3,5-dichloro-4-pyridinecarbonitrile towards nucleophil ic substitution of chlorine atoms and nucleophilic addition to the cya no group has been studied in presence of different nucleophiles and so lvents in order to evidence the best conditions for the synthesis of 3 ,4,5-trifunctionalized pyridines. Besides the products of substitution of only one chlorine atom, 3,5-bis(ethylthio)-4-pyridinecarbonitrile and 3,5-bis(tert-butylthio)-4-pyridinecarbonitrile have been prepared in high yields and the reduction of their cyano to amino group has bee n studied in order to obtain model molecules and new selective inhibit ors of extramitochondrial amine oxidase enzymes.