NOVEL SYNTHESES OF N-PIVOT LARIAT DIAZA-CROWN ETHERS FROM THYL)-4,13-DIAZA-1,7,10,16-TETRAOXACYCLOOCTADECANE

thyl)-4,13-diaza-1,7,10,16-tetraoxacyclooctadecane (6) was synthesized as a versatile intermediate in the preparation of bis(lariats) of dia za-18-crown-6. N,N'-Bis(umbelliferon-8-ylmethyl) derivative 8, bis(lar iats) with terminal unsaturated groups (11c,e), ester functionalities (11d), N,N'-di-beta-aralkyl derivatives (11a,b), and gamma-oxy-substit uted (13, 14) and gamma-amino-substituted (17-19) propylene-side-armed derivatives were thus prepared in moderate to excellent yields. The X -ray structure of bis(lariat) 6 and stability constants for several of the complexes of bis(lariats), derivatives of 6, with metal cations a re discussed.