UNILATERAL ADRENAL ENLARGEMENT DUE TO HISTOPLASMA-CAPSULATUM

Human infection with Histoplasma capsulatum runs the gamut from asympt omatic to disseminated disease. CT-directed fine-needle aspiration of bilaterally enlarged adrenal glands has been used in diagnosing seriou s infections with this ubiquitous organism. Three cases have previousl y been reported in which H. capsulatum infection caused unilateral adr enal enlargement; this enlargement was diagnosed post-mortem. We descr ibe three patients with unilateral adrenal enlargement due to H. capsu latum whose conditions were diagnosed antemortem, We encourage clinici ans to include infection with H. capsulatum as well as other granuloma tous diseases and tumors in the differential diagnosis of unilateral a drenal enlargement.