In the era of cost containment in health care, medical microbiology al
so faces the challenge of cost-effective use of microbiological diagno
stics. However, problems do not arise primarily within the laboratory
during analysis of clinical specimens, but also during the pre-analyti
cal stage, i.e. indication, sampling, storing and transporting of micr
obiological samples. This situation is emphasized drastically by the a
cronym GIGO,,,Garbage In, Garbage Out''. To overcome this unsatisfacto
ry situation both clinicians and microbiologists have to improve commu
nication and collaboration which is the basis for the rational diagnos
is of infection and therapy. Examples of inadequate microbiological in
vestigations together with the correct use of blood cultures are given
.