ENHANCEMENT OF LEFT-VENTRICULAR FUNCTION WITH ISOVOLUMETRIC HEMODILUTION AND GLUCOSE-INSULINE-KCL IN THE EARLY PHASE OF ACUTE MYOCARDIAL-INFARCTION IN DOGS

The effect of isovolumetric hemodilution with dextran 40 and glucose-i nsuline-KCl (GIK) were evaluated on the left ventricular function (+/- dp/dt-max, left ventricular systolic pressure:LVSP) in dogs with acut e myocardial infarction(AMI) during 6 hours. All animals were anesthet ized, chest opened and ventilated with pure oxygen, The results were a s follows. In the group of isovolumetric hemodilution or GIK infusion, + dp/dt-max increased se compared with that in the control group (no treatment res given after occlusion) (P < 0.06), and the GIK infusion, came into effect later than the former, In the group of the combinati on of the tao therapies, LVSP and - dp/dt-max elevated as compared wit h those in either of the tao groups, in each of which the animals were affected by only one therapy (P < 0.005). The results indicated that both isovolumetric hemodilution with dextran 40 and GIK infusion signi ficantly improve the left ventricular contractility in the early phase of AMI, that the GIK infusion took effect slowly, and that the combin ation of the tao therapies could not only further improve the left ven tricular contractility, but also enhance the relaxation significantly. It is demonstrated that the combination gives obvious coordinated eff ects. Copyright (C) 1996 Elsevier Science Ltd