S. Ikegawa et al., ISOLATION, CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF THE HUMAN WNT7A GENE, Cytogenetics and cell genetics, 74(1-2), 1996, pp. 149-152
The Wnt genes compose a large gene family encoding a group of secreted
signaling molecules that have been implicated in oncogenesis and a nu
mber of developmental processes. We have isolated a full-length human
cDNA clone that we consider to be a novel member of the Wnt gene famil
y. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98%
identity in amino acid sequence to murine Wnt7a. Expression of this ge
ne is restricted to certain tissues: placenta, kidney, testis, uterus,
fetal lung, and fetal and adult brain. Furthermore, we have isolated
a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluoresce
nt in situ hybridization.