A NOVEL RIBOSOMAL-PROTEIN L3-LIKE GENE (RPL3L) MAPS TO THE AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE GENE REGION

A full-length cDNA encoding a novel ribosomal protein L3 gene was isol ated and sequenced. The deduced protein sequence is 407 amino acids lo ng and shows 77% identity to other known mammalian ribosomal protein L 3 genes, which are themselves highly conserved. Southern blot analysis of human genomic DNA suggests that this novel gene is single copy. Wh ile the previously identified human ribosomal protein L3 gene has ubiq uitous expression in all tissues surveyed, the novel gene described he rein is strongly expressed in skeletal muscle and heart tissue, with l ow levels of expression in the pancreas. This novel gene, RPL3L, is lo cated in a gene-rich region near the PKD1 and TSC2 genes on chromosome 16p13.3. (C) 1996 Academic Press, Inc.