THE MOUSE X-LINKED DEVELOPMENTAL MUTANT, TATTERED, LIES BETWEEN DXMIT55 AND XKH AND IS ASSOCIATED WITH HYPERKERATINIZATION

The X-linked mouse mutant phenotype, tattered (Td), is associated with prenatal lethality of males and has been mapped previously to the pro ximal region of the mouse X chromosome, We report here a refined posit ion for Td and demonstrate that it lies in the similar to 0.9-cM inter val between DXMit55 and Xkh. This enables us to predict that the human homologue lies either between CLCN5 and the evolutionary breakpoint t hat lies between GATA1 and PFC or distal to XK and proximal to the evo lutionary breakpoint that lies between XK and DMD. Histological analys is of dorsal skin taken from 5-day-old heterozygous animals revealed t hat the mutation was associated with patches of hyperkeratinzation in the epidermis and in the hair follicles, accompanied by a mild inflamm atory infiltrate in the underlying dermis. (C) 1996 Academic Press, In c.