Ns. Aguilera et al., HODGKINS-DISEASE AND AN EXTRANODAL MARGINAL ZONE B-CELL LYMPHOMA IN THE SMALL-INTESTINE - AN UNUSUAL COMPOSITE LYMPHOMA, Modern pathology, 9(10), 1996, pp. 1020-1026
We describe a 74-year-old man who presented with multifocal small bowe
l lesions, a large mesenteric mass, and enlarged mesenteric lymph node
s, In each of the extranodal sites and in two of three regional lymph
nodes, there were classic histologic features of marginal zone B-cell
lymphoma with adjacent areas of Hodgkin's disease, mixed cellularity s
ubtype. Immunophenotypic analysis in the areas of low-grade B-cell lym
phoma of mucosa-associated lymphoid tissue showed immunoreactivity for
CD45RB and CD20 in the malignant small cell population Conversely, th
e areas of Hodgkin's disease demonstrated positive immunoreactivity fo
r CD15 and CD30 in the Reed-Sternberg cells and variants, Latent membr
ane protein for Epstein-Barr virus was also positive in the Reed-Stern
berg cells and variants.