HODGKINS-DISEASE AND AN EXTRANODAL MARGINAL ZONE B-CELL LYMPHOMA IN THE SMALL-INTESTINE - AN UNUSUAL COMPOSITE LYMPHOMA

We describe a 74-year-old man who presented with multifocal small bowe l lesions, a large mesenteric mass, and enlarged mesenteric lymph node s, In each of the extranodal sites and in two of three regional lymph nodes, there were classic histologic features of marginal zone B-cell lymphoma with adjacent areas of Hodgkin's disease, mixed cellularity s ubtype. Immunophenotypic analysis in the areas of low-grade B-cell lym phoma of mucosa-associated lymphoid tissue showed immunoreactivity for CD45RB and CD20 in the malignant small cell population Conversely, th e areas of Hodgkin's disease demonstrated positive immunoreactivity fo r CD15 and CD30 in the Reed-Sternberg cells and variants, Latent membr ane protein for Epstein-Barr virus was also positive in the Reed-Stern berg cells and variants.