Purpose: To evaluate the advantages, disadvantages, safety, complicati
ons, and surgical applicability of an erbium:YAG laser system for mane
uvers in vitreoretinal surgery. Methods: A prospective, consecutive tr
ial of 68 eyes in 66 patients undergoing vitreoretinal surgery in whic
h an erbium:YAG laser with graduated output from 0.2 to 5.0 mJ per pul
se, repetition rate of 2 to 30 Hz, and equipped with a flexible fiber
optic and interchangeable 20-gauge intraocular fiber optic endoprobes
was used to perform specific maneuvers, including transection, incisio
n, and ablation of membranes, retinotomy, vessel coagulation, iridecto
my, and lens tissue ablation. The patients were treated in five center
s in contemporary vitreoretinal surgical settings for surgical indicat
ions, including proliferative diabetic retinopathy, proliferative vitr
eoretinopathy, epiretinal membrane, and retinopathy of prematurity. Re
sults: One hundred seventy-four maneuvers were performed with an overa
ll surgical efficacy rating of excellent or good in 84% of maneuvers,
ranging from a high of 100% for subretinal membrane transection to a l
ow of 25% for coagulation of blood vessels. Complications included ret
inal break or photocoagulative injury in 5% of epiretinal membrane inc
isions, minor bleeding from transected retinal vessels during 29% of r
etinotomies, and intraocular lens damage during two posterior capsulot
omies. The most significant limitation was the cautious pace used duri
ng maneuvers near the retinal surface. Conclusion: The erbium:YAG lase
r is capable of versatile new approaches offering precise tissue cutti
ng and ablation in vitreoretinal surgical maneuvers with a high degree
of safety. The main limitation encountered was the slow speed of cert
ain critical maneuvers near the retina.