EVALUATION OF DIFFERENTIATION-INDUCING ACTIVITY OF RETINOIDS ON HUMANLEUKEMIA-CELL LINES HL-60 AND NB4

Authors
HASHIMOTO Y KAGECHIKA H KAWACHI E FUKASAWA H SAITO G SHUDO K
Citation
Y. Hashimoto et al., EVALUATION OF DIFFERENTIATION-INDUCING ACTIVITY OF RETINOIDS ON HUMANLEUKEMIA-CELL LINES HL-60 AND NB4, Biological & pharmaceutical bulletin, 19(10), 1996, pp. 1322-1328
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
19
Issue
10
Year of publication
1996
Pages
1322 - 1328
Database
ISI
SICI code
0918-6158(1996)19:10<1322:EODAOR>2.0.ZU;2-N
Abstract
Retinoids, including all-tr all-trans-retinoic acid (ATRA), its isomer s, and fifty synthetic retinoids (retinobenzoic acids), mere tested fo r differentiation-inducing activity on human leukemia cell lines HL-60 and NB4, Binding activity of typical retinoids to nuclear retinoic ac id receptors (RARs) was also investigated, A good linear correlation b etween the ED(50) values of differentiation-inducing activity towards HL-69 cells and those towards NB4 cells was found. Binding activities of retinoids to RAR alpha and RAR beta also correlated well to the dif ferentiation-inducing activities.