A PSEUDOLIKELIHOOD APPROACH TO CORRECTING FOR ASCERTAINMENT BIAS IN FAMILY STUDIES

Authors
RABINOWITZ D
Citation
D. Rabinowitz, A PSEUDOLIKELIHOOD APPROACH TO CORRECTING FOR ASCERTAINMENT BIAS IN FAMILY STUDIES, American journal of human genetics, 59(3), 1996, pp. 726-730
Citations number
22
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
59
Issue
3
Year of publication
1996
Pages
726 - 730
Database
ISI
SICI code
0002-9297(1996)59:3<726:APATCF>2.0.ZU;2-Q
Abstract
The Cannings and Thompson approach to correcting for ascertainment bia s in family studies is extended to settings with multiple ascertainmen t. The extension is based on maximizing a pseudolikelihood. Two approa ches to computing standard errors for the maximum pseudolikelihood est imate are described. One is especially simple to compute, while the ot her is more generally applicable. Simulation experiments suggest that the standard-error computations can be quite accurate.