THE EFFECT OF APROTININ ON THROMBELASTOGRAPHY IN-VITRO

Authors
CHALKIADIS GA GIBBS NM
Citation
Ga. Chalkiadis et Nm. Gibbs, THE EFFECT OF APROTININ ON THROMBELASTOGRAPHY IN-VITRO, Anaesthesia and intensive care, 24(5), 1996, pp. 552-554
Citations number
8
Categorie Soggetti
Anesthesiology,"Emergency Medicine & Critical Care
Journal title
Anaesthesia and intensive care → ACNP
ISSN journal
0310057X
Volume
24
Issue
5
Year of publication
1996
Pages
552 - 554
Database
ISI
SICI code
0310-057X(1996)24:5<552:TEOAOT>2.0.ZU;2-1
Abstract
The effect of low dose (50 KIU/ml) and high dose (200 KIU/ml) aprotini n on standard thrombelastographic variables (r; K, alpha, MA) was exam ined in vitro using blood from forty ASA Class I patients. Both concen trations of aprotinin resulted in minor increases in r time above the normal range (P < 0.05). Aprotinin did not alter other thrombelastogra phic variables, The results indicate that aprotinin is a mild direct a nticoagulant in vitro as assessed by thrombelastography.